Difference between revisions of "YLR205C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004195 YLR205C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004195 YLR205C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HMX1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HMX1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XII:553679..552726
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|nowrap| Chr XII:553677..552724
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004195
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004195
 
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'''Description of YLR205C:''' ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1<ref name='S000060699'>Foury F and Talibi D (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8 {{SGDpaper|S000060699}} PMID 11112771</ref><ref name='S000074012'>Protchenko O and Philpott CC (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7 {{SGDpaper|S000074012}} PMID 12840010</ref><ref name='S000073085'>Auclair K, et al. (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9
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'''Description of YLR205C:''' ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants<ref name='S000073085'>Auclair K, et al. (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9 {{SGDpaper|S000073085}} PMID 12699699</ref><ref name='S000140783'>Collinson EJ, et al. (2011) The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes. J Biol Chem 286(3):2205-14 {{SGDpaper|S000140783}} PMID 21081499</ref><ref name='S000060699'>Foury F and Talibi D (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8 {{SGDpaper|S000060699}} PMID 11112771</ref><ref name='S000119917'>Kim D, et al. (2006) Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45(49):14772-80 {{SGDpaper|S000119917}} PMID 17144670</ref><ref name='S000074012'>Protchenko O and Philpott CC (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7
  {{SGDpaper|S000073085}} PMID 12699699</ref>
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  {{SGDpaper|S000074012}} PMID 12840010</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YLR205C
Gene name HMX1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:553677..552724
Primary SGDID S000004195


Description of YLR205C: ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants[1][2][3][4][5]




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References

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  1. Auclair K, et al. (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9 SGD PMID 12699699
  2. Collinson EJ, et al. (2011) The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes. J Biol Chem 286(3):2205-14 SGD PMID 21081499
  3. Foury F and Talibi D (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8 SGD PMID 11112771
  4. Kim D, et al. (2006) Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45(49):14772-80 SGD PMID 17144670
  5. Protchenko O and Philpott CC (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7 SGD PMID 12840010

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