Difference between revisions of "YJL141C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003677 YJL141C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YAK1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YAK1 '' | ||
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| − | '''Description of YJL141C:''' Serine-threonine protein kinase | + | '''Description of YJL141C:''' Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose<ref name='S000043869'>Garrett S, et al. (1991) The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle. Mol Cell Biol 11(8):4045-52 {{SGDpaper|S000043869}} PMID 2072907</ref><ref name='S000046501'>Kassis S, et al. (2000) Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue. Biochem J 348 Pt 2():263-72 {{SGDpaper|S000046501}} PMID 10816418</ref><ref name='S000127771'>Lee P, et al. (2008) Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol 70(4):882-95 {{SGDpaper|S000127771}} PMID 18793336</ref><ref name='S000143765'>Lee P, et al. (2011) Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding. Mol Microbiol 79(3):633-46 {{SGDpaper|S000143765}} PMID 21255108</ref><ref name='S000080060'>Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 {{SGDpaper|S000080060}} PMID 15620355</ref><ref name='S000060336'>Moriya H, et al. (2001) Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev 15(10):1217-28 |
{{SGDpaper|S000060336}} PMID 11358866</ref> | {{SGDpaper|S000060336}} PMID 11358866</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YJL141C |
| Gene name | YAK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:150390..147967 |
| Primary SGDID | S000003677 |
Description of YJL141C: Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose[1][2][3][4][5][6]
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References
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- ↑ Garrett S, et al. (1991) The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle. Mol Cell Biol 11(8):4045-52 SGD PMID 2072907
- ↑ Kassis S, et al. (2000) Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue. Biochem J 348 Pt 2():263-72 SGD PMID 10816418
- ↑ Lee P, et al. (2008) Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol 70(4):882-95 SGD PMID 18793336
- ↑ Lee P, et al. (2011) Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding. Mol Microbiol 79(3):633-46 SGD PMID 21255108
- ↑ Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 SGD PMID 15620355
- ↑ Moriya H, et al. (2001) Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev 15(10):1217-28 SGD PMID 11358866
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