Difference between revisions of "YGR280C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003512 YGR280C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PXR1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PXR1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:1051725..1050910 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003512 | ||
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| − | '''Description of | + | '''Description of YGR280C:''' Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain<ref name='S000071554'>Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 {{SGDpaper|S000071554}} PMID 12107183</ref><ref name='S000076163'>Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 {{SGDpaper|S000076163}} PMID 14977919</ref><ref name='S000069787'>Zhou XZ and Lu KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107(3):347-59 |
{{SGDpaper|S000069787}} PMID 11701125</ref> | {{SGDpaper|S000069787}} PMID 11701125</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR280C |
| Gene name | PXR1 |
| Aliases | GNO1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:1051725..1050910 |
| Primary SGDID | S000003512 |
Description of YGR280C: Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain[1][2][3]
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References
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- ↑ Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 SGD PMID 12107183
- ↑ Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 SGD PMID 14977919
- ↑ Zhou XZ and Lu KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107(3):347-59 SGD PMID 11701125
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