Difference between revisions of "YGR231C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003463 YGR231C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PHB2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PHB2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:953480..952548 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003463 |
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| − | '''Description of | + | '''Description of YGR231C:''' Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation<ref name='S000050840'>Berger KH and Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043-52 {{SGDpaper|S000050840}} PMID 9632789</ref><ref name='S000045872'>Coates PJ, et al. (1997) The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol 7(8):607-10 {{SGDpaper|S000045872}} PMID 9259555</ref><ref name='S000050987'>Nijtmans LG, et al. (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444-51 {{SGDpaper|S000050987}} PMID 10835343</ref><ref name='S000073674'>Piper PW, et al. (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149-57 {{SGDpaper|S000073674}} PMID 12882345</ref><ref name='S000080623'>Tatsuta T, et al. (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59 |
| − | {{SGDpaper| | + | {{SGDpaper|S000080623}} PMID 15525670</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR231C |
| Gene name | PHB2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:953480..952548 |
| Primary SGDID | S000003463 |
Description of YGR231C: Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation[1][2][3][4][5]
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Contents
Community Commentary
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References
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- ↑ Berger KH and Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043-52 SGD PMID 9632789
- ↑ Coates PJ, et al. (1997) The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol 7(8):607-10 SGD PMID 9259555
- ↑ Nijtmans LG, et al. (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444-51 SGD PMID 10835343
- ↑ Piper PW, et al. (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149-57 SGD PMID 12882345
- ↑ Tatsuta T, et al. (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59 SGD PMID 15525670
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