Difference between revisions of "YGR202C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003434 YGR202C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PCT1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PCT1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:904748..903474 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003434 | ||
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| − | '''Description of | + | '''Description of YGR202C:''' Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding<ref name='S000059477'>Dowd SR, et al. (2001) Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway. J Biol Chem 276(6):3756-63 {{SGDpaper|S000059477}} PMID 11078727</ref><ref name='S000064321'>Friesen JA, et al. (2001) Purification and kinetic characterization of CTP:phosphocholine cytidylyltransferase from Saccharomyces cerevisiae. Protein Expr Purif 21(1):141-8 {{SGDpaper|S000064321}} PMID 11162399</ref><ref name='S000045374'>Skinner HB, et al. (1995) The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity. Proc Natl Acad Sci U S A 92(1):112-6 {{SGDpaper|S000045374}} PMID 7816798</ref><ref name='S000051159'>Sreenivas A, et al. (1998) A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J Biol Chem 273(27):16635-8 {{SGDpaper|S000051159}} PMID 9642212</ref><ref name='S000056938'>Tsukagoshi Y, et al. (1987) Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae. Eur J Biochem 169(3):477-86 |
| − | {{SGDpaper| | + | {{SGDpaper|S000056938}} PMID 2826147</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR202C |
| Gene name | PCT1 |
| Aliases | BSR2, CCT1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:904748..903474 |
| Primary SGDID | S000003434 |
Description of YGR202C: Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding[1][2][3][4][5]
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References
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- ↑ Dowd SR, et al. (2001) Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway. J Biol Chem 276(6):3756-63 SGD PMID 11078727
- ↑ Friesen JA, et al. (2001) Purification and kinetic characterization of CTP:phosphocholine cytidylyltransferase from Saccharomyces cerevisiae. Protein Expr Purif 21(1):141-8 SGD PMID 11162399
- ↑ Skinner HB, et al. (1995) The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity. Proc Natl Acad Sci U S A 92(1):112-6 SGD PMID 7816798
- ↑ Sreenivas A, et al. (1998) A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J Biol Chem 273(27):16635-8 SGD PMID 9642212
- ↑ Tsukagoshi Y, et al. (1987) Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae. Eur J Biochem 169(3):477-86 SGD PMID 2826147
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