Difference between revisions of "YDR363W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002771 YDR363W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002771 YDR363W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''ESC2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''ESC2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:1199176..1200546
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|nowrap| Chr IV:1199183..1200553
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002771
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002771
 
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'''Description of YDR363W:''' Protein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homologous recombination repair and intra S-phase DNA damage checkpoint; member of the RENi (Rad60-Esc2-Nip45) family of SUMO-like domain proteins<ref name='S000128989'>Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 {{SGDpaper|S000128989}} PMID 19158388</ref><ref name='S000080832'>Novatchkova M, et al. (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6:22 {{SGDpaper|S000080832}} PMID 15698469</ref><ref name='S000071547'>Cuperus G and Shore D (2002) Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8. Genetics 162(2):633-45 {{SGDpaper|S000071547}} PMID 12399377</ref><ref name='S000056456'>Dhillon N and Kamakaka RT (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80
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'''Description of YDR363W:''' Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member<ref name='S000133981'>Choi K, et al. (2010) The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2306-14 {{SGDpaper|S000133981}} PMID 20444977</ref><ref name='S000056456'>Dhillon N and Kamakaka RT (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80 {{SGDpaper|S000056456}} PMID 11090616</ref><ref name='S000128989'>Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 {{SGDpaper|S000128989}} PMID 19158388</ref><ref name='S000080832'>Novatchkova M, et al. (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6():22 {{SGDpaper|S000080832}} PMID 15698469</ref><ref name='S000127611'>Ohya T, et al. (2008) A SUMO-Like Domain Protein, Esc2, Is Required for Genome Integrity and Sister Chromatid Cohesion in Saccharomyces cerevisiae. Genetics 180(1):41-50
  {{SGDpaper|S000056456}} PMID 11090616</ref>
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  {{SGDpaper|S000127611}} PMID 18757937</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YDR363W
Gene name ESC2
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1199183..1200553
Primary SGDID S000002771


Description of YDR363W: Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member[1][2][3][4][5]




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References

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  1. Jump up Choi K, et al. (2010) The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2306-14 SGD PMID 20444977
  2. Jump up Dhillon N and Kamakaka RT (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80 SGD PMID 11090616
  3. Jump up Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 SGD PMID 19158388
  4. Jump up Novatchkova M, et al. (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6():22 SGD PMID 15698469
  5. Jump up Ohya T, et al. (2008) A SUMO-Like Domain Protein, Esc2, Is Required for Genome Integrity and Sister Chromatid Cohesion in Saccharomyces cerevisiae. Genetics 180(1):41-50 SGD PMID 18757937

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