Difference between revisions of "YDR047W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002454 YDR047W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HEM12 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HEM12 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:551860..552948 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002454 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002454 | ||
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| − | '''Description of YDR047W:''' Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; | + | '''Description of YDR047W:''' Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda<ref name='S000056779'>Felix F and Brouillet N (1990) Purification and properties of uroporphyrinogen decarboxylase from Saccharomyces cerevisiae. Yeast uroporphyrinogen decarboxylase. Eur J Biochem 188(2):393-403 {{SGDpaper|S000056779}} PMID 2180703</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000057278'>Rytka J, et al. (1984) Modified uroporphyrinogen decarboxylase activity in a yeast mutant which mimics porphyria cutanea tarda. Biochem J 218(2):405-13 {{SGDpaper|S000057278}} PMID 6370240</ref><ref name='S000057328'>Urban-Grimal D and Labbe-Bois R (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92 |
| − | + | {{SGDpaper|S000057328}} PMID 7035824</ref> | |
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YDR047W |
| Gene name | HEM12 |
| Aliases | HEM6 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:551860..552948 |
| Primary SGDID | S000002454 |
Description of YDR047W: Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda[1][2][3][4]
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References
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- ↑ Felix F and Brouillet N (1990) Purification and properties of uroporphyrinogen decarboxylase from Saccharomyces cerevisiae. Yeast uroporphyrinogen decarboxylase. Eur J Biochem 188(2):393-403 SGD PMID 2180703
- ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
- ↑ Rytka J, et al. (1984) Modified uroporphyrinogen decarboxylase activity in a yeast mutant which mimics porphyria cutanea tarda. Biochem J 218(2):405-13 SGD PMID 6370240
- ↑ Urban-Grimal D and Labbe-Bois R (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92 SGD PMID 7035824
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