Difference between revisions of "YDL003W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002161 YDL003W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MCD1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MCD1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:444683..446383 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002161 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002161 | ||
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| − | '''Description of YDL003W:''' Essential | + | '''Description of YDL003W:''' Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase<ref name='S000054347'>Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 {{SGDpaper|S000054347}} PMID 9335334</ref><ref name='S000125750'>Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 |
| − | {{SGDpaper| | + | {{SGDpaper|S000125750}} PMID 18321989</ref> |
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDL003W |
| Gene name | MCD1 |
| Aliases | PDS3, RHC21, SCC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:444683..446383 |
| Primary SGDID | S000002161 |
Description of YDL003W: Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase[1][2]
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Community Commentary
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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008
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References
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- ↑ Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334
- ↑ Yang H, et al. (2008) Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol Biol Cell 19(5):2127-34 SGD PMID 18321989
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References
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See Help:Categories on how to add the wiki page for this gene to a Category </protect>
