Difference between revisions of "YKR071C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001779 YKR071C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001779 YKR071C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DRE2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DRE2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:575622..574576
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|nowrap| Chr XI:575980..574934
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001779
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001779
 
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'''Description of YKR071C:''' Protein of unknown function required for iron-sulfur cluster assembly and sister chromatid cohesion; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2<ref name='S000127099'>Zhang Y, et al. (2008) Dre2, a conserved eukaryotic fe/s cluster protein, functions in cytosolic fe/s protein biogenesis. Mol Cell Biol 28(18):5569-82 {{SGDpaper|S000127099}} PMID 18625724</ref><ref name='S000126287'>Ben-Aroya S, et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58 {{SGDpaper|S000126287}} PMID 18439903</ref><ref name='S000073937'>Chanet R and Heude M (2003) Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet 43(5):337-50
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'''Description of YKR071C:''' Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1<ref name='S000136241'>Netz DJ, et al. (2010) Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol 6(10):758-65 {{SGDpaper|S000136241}} PMID 20802492</ref><ref name='S000129193'>Vernis L, et al. (2009) A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS ONE 4(2):e4376 {{SGDpaper|S000129193}} PMID 19194512</ref><ref name='S000127099'>Zhang Y, et al. (2008) Dre2, a conserved eukaryotic fe/s cluster protein, functions in cytosolic fe/s protein biogenesis. Mol Cell Biol 28(18):5569-82
  {{SGDpaper|S000073937}} PMID 12759774</ref>
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  {{SGDpaper|S000127099}} PMID 18625724</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YKR071C
Gene name DRE2
Aliases
Feature type ORF, Verified
Coordinates Chr XI:575980..574934
Primary SGDID S000001779


Description of YKR071C: Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1[1][2][3]




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References

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  1. Netz DJ, et al. (2010) Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol 6(10):758-65 SGD PMID 20802492
  2. Vernis L, et al. (2009) A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS ONE 4(2):e4376 SGD PMID 19194512
  3. Zhang Y, et al. (2008) Dre2, a conserved eukaryotic fe/s cluster protein, functions in cytosolic fe/s protein biogenesis. Mol Cell Biol 28(18):5569-82 SGD PMID 18625724

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