Difference between revisions of "YKL217W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001700 YKL217W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''JEN1 ''
 
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'''Description of YKL217W:''' Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose<ref name='S000123951'>Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 {{SGDpaper|S000123951}} PMID 17761666</ref><ref name='S000056432'>Akita O, et al. (2000) Transport of pyruvate in Saccharomyces cerevisiae and cloning of the gene encoded pyruvate permease. Biosci Biotechnol Biochem 64(5):980-4 {{SGDpaper|S000056432}} PMID 10879467</ref><ref name='S000053081'>Casal M, et al. (1999) The lactate-proton symport of Saccharomyces cerevisiae is encoded by JEN1. J Bacteriol 181(8):2620-3 {{SGDpaper|S000053081}} PMID 10198029</ref><ref name='S000043068'>Haurie V, et al. (2001) The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 276(1):76-85
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'''Description of YKL217W:''' Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose<ref name='S000056432'>Akita O, et al. (2000) Transport of pyruvate in Saccharomyces cerevisiae and cloning of the gene encoded pyruvate permease. Biosci Biotechnol Biochem 64(5):980-4 {{SGDpaper|S000056432}} PMID 10879467</ref><ref name='S000082035'>Andrade RP, et al. (2005) Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae. Biochem Biophys Res Commun 332(1):254-62 {{SGDpaper|S000082035}} PMID 15896325</ref><ref name='S000053081'>Casal M, et al. (1999) The lactate-proton symport of Saccharomyces cerevisiae is encoded by JEN1. J Bacteriol 181(8):2620-3 {{SGDpaper|S000053081}} PMID 10198029</ref><ref name='S000074645'>Chambers P, et al. (2004) Saccharomyces cerevisiae JEN1 promoter activity is inversely related to concentration of repressing sugar. Appl Environ Microbiol 70(1):8-17 {{SGDpaper|S000074645}} PMID 14711620</ref><ref name='S000043068'>Haurie V, et al. (2001) The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 276(1):76-85 {{SGDpaper|S000043068}} PMID 11024040</ref><ref name='S000136713'>McDermott JR, et al. (2010) Jen1p: a high affinity selenite transporter in yeast. Mol Biol Cell 21(22):3934-41 {{SGDpaper|S000136713}} PMID 20861301</ref><ref name='S000069688'>Paiva S, et al. (2002) Utilization of green fluorescent protein as a marker for studying the expression and turnover of the monocarboxylate permease Jen1p of Saccharomyces cerevisiae. Biochem J 363(Pt 3):737-44 {{SGDpaper|S000069688}} PMID 11964174</ref><ref name='S000123872'>Soares-Silva I, et al. (2007) The conserved sequence NXX[S/T]HX[S/T]QDXXXT of the lactate/pyruvate:H(+) symporter subfamily defines the function of the substrate translocation pathway. Mol Membr Biol 24(5):464-74
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Latest revision as of 06:45, 23 January 2012

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Systematic name YKL217W
Gene name JEN1
Aliases
Feature type ORF, Verified
Coordinates Chr XI:22234..24084
Primary SGDID S000001700


Description of YKL217W: Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose[1][2][3][4][5][6][7][8]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in sulfur limited chemostat cultures versus sulfur excess. [9] [10]

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [9] [10]




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References

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  1. ↑ Akita O, et al. (2000) Transport of pyruvate in Saccharomyces cerevisiae and cloning of the gene encoded pyruvate permease. Biosci Biotechnol Biochem 64(5):980-4 SGD PMID 10879467
  2. ↑ Andrade RP, et al. (2005) Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae. Biochem Biophys Res Commun 332(1):254-62 SGD PMID 15896325
  3. ↑ Casal M, et al. (1999) The lactate-proton symport of Saccharomyces cerevisiae is encoded by JEN1. J Bacteriol 181(8):2620-3 SGD PMID 10198029
  4. ↑ Chambers P, et al. (2004) Saccharomyces cerevisiae JEN1 promoter activity is inversely related to concentration of repressing sugar. Appl Environ Microbiol 70(1):8-17 SGD PMID 14711620
  5. ↑ Haurie V, et al. (2001) The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 276(1):76-85 SGD PMID 11024040
  6. ↑ McDermott JR, et al. (2010) Jen1p: a high affinity selenite transporter in yeast. Mol Biol Cell 21(22):3934-41 SGD PMID 20861301
  7. ↑ Paiva S, et al. (2002) Utilization of green fluorescent protein as a marker for studying the expression and turnover of the monocarboxylate permease Jen1p of Saccharomyces cerevisiae. Biochem J 363(Pt 3):737-44 SGD PMID 11964174
  8. ↑ Soares-Silva I, et al. (2007) The conserved sequence NXX[S/T]HX[S/T]QDXXXT of the lactate/pyruvate:H(+) symporter subfamily defines the function of the substrate translocation pathway. Mol Membr Biol 24(5):464-74 SGD PMID 17710650
  9. ↑ 9.0 9.1 Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  10. ↑ 10.0 10.1 submitted by Viktor Boer on 2003-07-25

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