Difference between revisions of "YER041W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000843 YER041W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000843 YER041W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''YEN1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''YEN1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr V:232460..234739
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|nowrap| Chr V:232461..234740
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000843
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000843
 
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'''Description of YER041W:''' Holliday junction resolvase; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p; potentially phosphorylated by Cdc28p<ref name='S000051194'>Johnson RE, et al. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr Genet 34(1):21-9 {{SGDpaper|S000051194}} PMID 9683672</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000128360'>Ip SC, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456(7220):357-361
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'''Description of YER041W:''' Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p<ref name='S000128360'>Ip SC, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456(7220):357-361 {{SGDpaper|S000128360}} PMID 19020614</ref><ref name='S000051194'>Johnson RE, et al. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr Genet 34(1):21-9 {{SGDpaper|S000051194}} PMID 9683672</ref><ref name='S000130607'>Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106(25):10171-6 {{SGDpaper|S000130607}} PMID 19520826</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
  {{SGDpaper|S000128360}} PMID 19020614</ref>
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  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YER041W
Gene name YEN1
Aliases
Feature type ORF, Verified
Coordinates Chr V:232461..234740
Primary SGDID S000000843


Description of YER041W: Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Ip SC, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456(7220):357-361 SGD PMID 19020614
  2. Johnson RE, et al. (1998) Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. Curr Genet 34(1):21-9 SGD PMID 9683672
  3. Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106(25):10171-6 SGD PMID 19520826
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. submitted by Jeff Ubersax on 2004-01-27

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