Difference between revisions of "YEL062W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000788 YEL062W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NPR2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NPR2 '' | ||
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| − | '''Description of YEL062W:''' | + | '''Description of YEL062W:''' Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline<ref name='S000144831'>Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics () {{SGDpaper|S000144831}} PMID 21454883</ref><ref name='S000130605'>Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515 {{SGDpaper|S000130605}} PMID 19521502</ref><ref name='S000046769'>Rousselet G, et al. (1995) A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett 359(2-3):215-9 {{SGDpaper|S000046769}} PMID 7867803</ref><ref name='S000073889'>Schenk PW, et al. (2003) Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill. Mol Pharmacol 64(2):259-68 {{SGDpaper|S000073889}} PMID 12869630</ref><ref name='S000133200'>Spielewoy N, et al. (2010) Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot Cell 9(4):592-601 {{SGDpaper|S000133200}} PMID 20154027</ref><ref name='S000146640'>Wu X and Tu BP (2011) Selective Regulation of Autophagy by the Iml1p-Npr2p-Npr3p Complex in the Absence of Nitrogen Starvation. Mol Biol Cell () |
| − | {{SGDpaper| | + | {{SGDpaper|S000146640}} PMID 21900499</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YEL062W |
| Gene name | NPR2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:34407..36254 |
| Primary SGDID | S000000788 |
Description of YEL062W: Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline[1][2][3][4][5][6]
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References
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- ↑ Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics () SGD PMID 21454883
- ↑ Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515 SGD PMID 19521502
- ↑ Rousselet G, et al. (1995) A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett 359(2-3):215-9 SGD PMID 7867803
- ↑ Schenk PW, et al. (2003) Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill. Mol Pharmacol 64(2):259-68 SGD PMID 12869630
- ↑ Spielewoy N, et al. (2010) Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot Cell 9(4):592-601 SGD PMID 20154027
- ↑ Wu X and Tu BP (2011) Selective Regulation of Autophagy by the Iml1p-Npr2p-Npr3p Complex in the Absence of Nitrogen Starvation. Mol Biol Cell () SGD PMID 21900499
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