Difference between revisions of "YBR080C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000284 YBR080C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000284 YBR080C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC18 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC18 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr II:400884..398608
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|nowrap| Chr II:400890..398614
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000284
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000284
 
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'''Description of YBR080C:''' ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF<ref name='S000073403'>Kato M and Wickner W (2003) Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering. Proc Natl Acad Sci U S A 100(11):6398-403 {{SGDpaper|S000073403}} PMID 12748377</ref><ref name='S000052079'>Mayer A, et al. (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94 {{SGDpaper|S000052079}} PMID 8620540</ref><ref name='S000047231'>Newman AP and Ferro-Novick S (1990) Defining components required for transport from the ER to the Golgi complex in yeast. Bioessays 12(10):485-91
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'''Description of YBR080C:''' ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF<ref name='S000052079'>Mayer A, et al. (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94 {{SGDpaper|S000052079}} PMID 8620540</ref><ref name='S000047231'>Newman AP and Ferro-Novick S (1990) Defining components required for transport from the ER to the Golgi complex in yeast. Bioessays 12(10):485-91 {{SGDpaper|S000047231}} PMID 2082939</ref><ref name='S000055337'>Ungermann C, et al. (1998) A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion. J Cell Biol 140(1):61-9 {{SGDpaper|S000055337}} PMID 9425154</ref><ref name='S000041103'>Wilson DW, et al. (1989) A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature 339(6223):355-9
  {{SGDpaper|S000047231}} PMID 2082939</ref>
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  {{SGDpaper|S000041103}} PMID 2657434</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YBR080C
Gene name SEC18
Aliases ANU4
Feature type ORF, Verified
Coordinates Chr II:400890..398614
Primary SGDID S000000284


Description of YBR080C: ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF[1][2][3][4]




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References

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  1. Mayer A, et al. (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94 SGD PMID 8620540
  2. Newman AP and Ferro-Novick S (1990) Defining components required for transport from the ER to the Golgi complex in yeast. Bioessays 12(10):485-91 SGD PMID 2082939
  3. Ungermann C, et al. (1998) A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion. J Cell Biol 140(1):61-9 SGD PMID 9425154
  4. Wilson DW, et al. (1989) A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature 339(6223):355-9 SGD PMID 2657434

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