Difference between revisions of "YBL008W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBL008W YBL008W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000104 YBL008W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HIR1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HIR1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr II:209656..212178
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|nowrap| Chr II:209653..212175
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000104
 
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'''Description of {{PAGENAME}}:''' Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores<ref name='S000069112'>Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 {{SGDpaper|S000069112}} PMID 11782447</ref><ref name='S000065877'>Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 {{SGDpaper|S000065877}} PMID 11412995</ref><ref name='S000055143'>Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 {{SGDpaper|S000055143}} PMID 9001207</ref><ref name='S000048249'>Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 {{SGDpaper|S000048249}} PMID 8417331</ref><ref name='S000043368'>Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 {{SGDpaper|S000043368}} PMID 9671489</ref><ref name='S000039248'>DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67
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'''Description of YBL008W:''' Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores<ref name='S000039248'>DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67 {{SGDpaper|S000039248}} PMID 9504914</ref><ref name='S000043368'>Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 {{SGDpaper|S000043368}} PMID 9671489</ref><ref name='S000087068'>Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 {{SGDpaper|S000087068}} PMID 16264190</ref><ref name='S000065877'>Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 {{SGDpaper|S000065877}} PMID 11412995</ref><ref name='S000069112'>Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 {{SGDpaper|S000069112}} PMID 11782447</ref><ref name='S000048249'>Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 {{SGDpaper|S000048249}} PMID 8417331</ref><ref name='S000055143'>Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YBL008W
Gene name HIR1
Aliases
Feature type ORF, Verified
Coordinates Chr II:209653..212175
Primary SGDID S000000104


Description of YBL008W: Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores[1][2][3][4][5][6][7]




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References

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  1. Jump up ↑ DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67 SGD PMID 9504914
  2. Jump up ↑ Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 SGD PMID 9671489
  3. Jump up ↑ Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 SGD PMID 16264190
  4. Jump up ↑ Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 SGD PMID 11412995
  5. Jump up ↑ Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 SGD PMID 11782447
  6. Jump up ↑ Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 SGD PMID 8417331
  7. Jump up ↑ Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 SGD PMID 9001207

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