Difference between revisions of "YAL040C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000038 YAL040C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CLN3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CLN3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr I: | + | |nowrap| Chr I:67520..65778 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000038 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000038 | ||
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| − | '''Description of YAL040C:''' G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis<ref name=' | + | '''Description of YAL040C:''' G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis<ref name='S000039355'>Cross FR and Blake CM (1993) The yeast Cln3 protein is an unstable activator of Cdc28. Mol Cell Biol 13(6):3266-71 {{SGDpaper|S000039355}} PMID 8497251</ref><ref name='S000041102'>Nash R, et al. (1988) The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J 7(13):4335-46 {{SGDpaper|S000041102}} PMID 2907481</ref><ref name='S000052440'>Tyers M, et al. (1992) The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J 11(5):1773-84 |
| − | {{SGDpaper| | + | {{SGDpaper|S000052440}} PMID 1316273</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YAL040C |
| Gene name | CLN3 |
| Aliases | DAF1, FUN10, WHI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr I:67520..65778 |
| Primary SGDID | S000000038 |
Description of YAL040C: G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Cross FR and Blake CM (1993) The yeast Cln3 protein is an unstable activator of Cdc28. Mol Cell Biol 13(6):3266-71 SGD PMID 8497251
- ↑ Nash R, et al. (1988) The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J 7(13):4335-46 SGD PMID 2907481
- ↑ Tyers M, et al. (1992) The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J 11(5):1773-84 SGD PMID 1316273
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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