Difference between revisions of "YAL026C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000024 YAL026C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DRS2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DRS2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr I: | + | |nowrap| Chr I:99697..95630 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000024 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000024 | ||
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| − | '''Description of YAL026C:''' Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory | + | '''Description of YAL026C:''' Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease<ref name='S000114386'>Alder-Baerens N, et al. (2006) Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol Biol Cell 17(4):1632-42 {{SGDpaper|S000114386}} PMID 16452632</ref><ref name='S000122180'>Bull LN, et al. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18(3):219-24 {{SGDpaper|S000122180}} PMID 9500542</ref><ref name='S000040586'>Chen CY, et al. (1999) Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. J Cell Biol 147(6):1223-36 {{SGDpaper|S000040586}} PMID 10601336</ref><ref name='S000072790'>Gall WE, et al. (2002) Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Curr Biol 12(18):1623-7 {{SGDpaper|S000072790}} PMID 12372257</ref><ref name='S000076944'>Natarajan P, et al. (2004) Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci U S A 101(29):10614-9 {{SGDpaper|S000076944}} PMID 15249668</ref><ref name='S000075362'>Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
| − | + | {{SGDpaper|S000075362}} PMID 12631737</ref> | |
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YAL026C |
| Gene name | DRS2 |
| Aliases | FUN38, SWA3 |
| Feature type | ORF, Verified |
| Coordinates | Chr I:99697..95630 |
| Primary SGDID | S000000024 |
Description of YAL026C: Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease[1][2][3][4][5][6]
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References
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- ↑ Alder-Baerens N, et al. (2006) Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol Biol Cell 17(4):1632-42 SGD PMID 16452632
- ↑ Bull LN, et al. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18(3):219-24 SGD PMID 9500542
- ↑ Chen CY, et al. (1999) Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. J Cell Biol 147(6):1223-36 SGD PMID 10601336
- ↑ Gall WE, et al. (2002) Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Curr Biol 12(18):1623-7 SGD PMID 12372257
- ↑ Natarajan P, et al. (2004) Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci U S A 101(29):10614-9 SGD PMID 15249668
- ↑ Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 SGD PMID 12631737
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