Difference between revisions of "YPL008W"
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− | '''Description of YPL008W:''' Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member<ref name='S000086863'>Das SP and Sinha P (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochem Biophys Res Commun 337(1):167-72 {{SGDpaper|S000086863}} PMID 16182251</ref><ref name='S000076406'>Skibbens RV (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42 {{SGDpaper|S000076406}} PMID 15020404</ref><ref name='S000128804'>Wu Y, et al. (2009) Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci 66(7):1209-22 | + | '''Description of YPL008W:''' Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome<ref name='S000086863'>Das SP and Sinha P (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochem Biophys Res Commun 337(1):167-72 {{SGDpaper|S000086863}} PMID 16182251</ref><ref name='S000076406'>Skibbens RV (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42 {{SGDpaper|S000076406}} PMID 15020404</ref><ref name='S000128804'>Wu Y, et al. (2009) Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci 66(7):1209-22 {{SGDpaper|S000128804}} PMID 19099189</ref><ref name='S000147534'>Wu Y, et al. (2011) Biochemical characterization of Warsaw Breakage Syndrome helicase. J Biol Chem () |
− | {{SGDpaper| | + | {{SGDpaper|S000147534}} PMID 22102414</ref> |
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Revision as of 14:05, 3 January 2012
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Systematic name | YPL008W |
Gene name | CHL1 |
Aliases | CTF1, LPA9, MCM12 |
Feature type | ORF, Verified |
Coordinates | Chr XVI:539385..541970 |
Primary SGDID | S000005929 |
Description of YPL008W: Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome[1][2][3][4]
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References
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- ↑ Das SP and Sinha P (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochem Biophys Res Commun 337(1):167-72 SGD PMID 16182251
- ↑ Skibbens RV (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42 SGD PMID 15020404
- ↑ Wu Y, et al. (2009) Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci 66(7):1209-22 SGD PMID 19099189
- ↑ Wu Y, et al. (2011) Biochemical characterization of Warsaw Breakage Syndrome helicase. J Biol Chem () SGD PMID 22102414
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