Difference between revisions of "tL(UAA)Q"
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| − | '''Description of tL(UAA)Q:''' Mitochondrial tRNA-Leu, required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS<ref name='S000115647'>Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8 | + | '''Description of tL(UAA)Q:''' Mitochondrial leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS<ref name='S000147623'>Chan PP and Lowe TM (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7 {{SGDpaper|S000147623}} PMID 18984615</ref><ref name='S000115647'>Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8 {{SGDpaper|S000115647}} PMID 12524521</ref><ref name='S000058438'>Foury F, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31 |
| − | {{SGDpaper| | + | {{SGDpaper|S000058438}} PMID 9872396</ref> |
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Revision as of 13:05, 6 December 2011
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| Systematic name | tL(UAA)Q |
| Gene name | |
| Aliases | |
| Feature type | tRNA |
| Coordinates | Mito:66095..66179 |
| Primary SGDID | S000007324 |
Description of tL(UAA)Q: Mitochondrial leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS[1][2][3]
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References
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- ↑ Chan PP and Lowe TM (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7 SGD PMID 18984615
- ↑ Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8 SGD PMID 12524521
- ↑ Foury F, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31 SGD PMID 9872396
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