Difference between revisions of "YPL164C"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YPL164C
Gene name MLH3
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:241496..239349


Description of YPL164C: Protein involved in DNA mismatch repair; forms a complex with Mlh1p to promote meiotic crossing-over; mammalian homolog is implicated mammalian microsatellite instability[1][2][3][4]




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Community Commentary

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References

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  1. Lipkin SM, et al. (2000) MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet 24(1):27-35 SGD PMID 10615123
  2. Wang TF, et al. (1999) Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc Natl Acad Sci U S A 96(24):13914-9 SGD PMID 10570173
  3. Flores-Rozas H and Kolodner RD (1998) The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A 95(21):12404-9 SGD PMID 9770499
  4. Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8 SGD PMID 10679328

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