Difference between revisions of "YPL154C"

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==Community Commentary==
 
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==References==
 
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Revision as of 07:18, 30 January 2007

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Systematic name YPL154C
Gene name PEP4
Aliases PHO9, PRA1, yscA
Feature type ORF, Verified
Coordinates Chr XVI:260930..259713


Description of YPL154C: Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates[1][2][3][4][5][6]




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Community Commentary

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References

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  1. Woolford CA, et al. (1986) The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolases. Mol Cell Biol 6(7):2500-10 SGD PMID 3537721
  2. Ammerer G, et al. (1986) PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors. Mol Cell Biol 6(7):2490-9 SGD PMID 3023936
  3. Wolff AM, et al. (1996) Vacuolar and extracellular maturation of Saccharomyces cerevisiae proteinase A. Yeast 12(9):823-32 SGD PMID 8840499
  4. van den Hazel HB, et al. (1992) Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens. Eur J Biochem 207(1):277-83 SGD PMID 1628653
  5. van den Hazel HB, et al. (1993) The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region. J Biol Chem 268(24):18002-7 SGD PMID 8349680
  6. Rupp S and Wolf DH (1995) Biogenesis of the yeast vacuole (lysosome). The use of active-site mutants of proteinase yscA to determine the necessity of the enzyme for vacuolar proteinase maturation and proteinase yscB stability. Eur J Biochem 231(1):115-25 SGD PMID 7628461

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