Difference between revisions of "YPL139C"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YPL139C
Gene name UME1
Aliases WTM3
Feature type ORF, Verified
Coordinates Chr XVI:291050..289668


Description of YPL139C: Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p[1][2][3][4]




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Community Commentary

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References

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  1. Mallory MJ and Strich R (2003) Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. J Biol Chem 278(45):44727-34 SGD PMID 12954623
  2. Kurdistani SK, et al. (2002) Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet 31(3):248-54 SGD PMID 12089521
  3. Strich R, et al. (1989) Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A 86(24):10018-22 SGD PMID 2690066
  4. Pemberton LF and Blobel G (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41 SGD PMID 9234739

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