Difference between revisions of "YMR190C"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YMR190C
Gene name SGS1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:645257..640914


Description of YMR190C: Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes[1][2][3][4]




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Community Commentary

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References

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  1. Rockmill B, et al. (2003) The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over. Curr Biol 13(22):1954-62 SGD PMID 14614820
  2. Versini G, et al. (2003) The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication. EMBO J 22(8):1939-49 SGD PMID 12682026
  3. Huber MD, et al. (2002) G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res 30(18):3954-61 SGD PMID 12235379
  4. Sun H, et al. (1999) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res 27(9):1978-84 SGD PMID 10198430

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