Difference between revisions of "YMR106C"

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==Community Commentary==
 
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==References==
 
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Revision as of 07:18, 30 January 2007

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Systematic name YMR106C
Gene name YKU80
Aliases HDF2
Feature type ORF, Verified
Coordinates Chr XIII:480189..478300


Description of YMR106C: Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair[1][2][3][4][5][6]




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Community Commentary

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References

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  1. Bertuch AA and Lundblad V (2003) The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol 23(22):8202-15 SGD PMID 14585978
  2. Boulton SJ and Jackson SP (1996) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res 24(23):4639-48 SGD PMID 8972848
  3. Laroche T, et al. (1998) Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr Biol 8(11):653-6 SGD PMID 9635192
  4. Boulton SJ and Jackson SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 17(6):1819-28 SGD PMID 9501103
  5. Milne GT, et al. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4189-98 SGD PMID 8754818
  6. Martin SG, et al. (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97(5):621-33 SGD PMID 10367891

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