Difference between revisions of "YLR220W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YLR220W
Gene name CCC1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:576827..577795


Description of YLR220W: Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation[1][2][3]




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References

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  1. Li L, et al. (2001) CCC1 is a transporter that mediates vacuolar iron storage in yeast. J Biol Chem 276(31):29515-9 SGD PMID 11390404
  2. Lapinskas PJ, et al. (1996) The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Mol Microbiol 21(3):519-28 SGD PMID 8866476
  3. Chen OS and Kaplan J (2000) CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation. J Biol Chem 275(11):7626-32 SGD PMID 10713071

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