Difference between revisions of "YJL084C"

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'''Description of YJL084C:''' Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase<ref name='S000069459'>Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 {{SGDpaper|S000069459}} PMID 11914276</ref><ref name='S000070355'>Shi XZ and Ao SZ (2002) Analysis of phosphorylation of YJL084c, a yeast protein. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34(4):433-8 {{SGDpaper|S000070355}} PMID 12098764</ref><ref name='S000087197'>de Lichtenberg U, et al. (2005) New weakly expressed cell cycle-regulated genes in yeast. Yeast 22(15):1191-201
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'''Description of YJL084C:''' Protein that promotes endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; acts as an adaptor to bring together Rsp5p with substrate Dip5p; phosphorylated by cyclin-CDK complex Pcl7p-Pho85p<ref name='S000138851'>Hatakeyama R, et al. (2010) Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2. Mol Cell Biol 30(24):5598-607 {{SGDpaper|S000138851}} PMID 20956561</ref><ref name='S000070355'>Shi XZ and Ao SZ (2002) Analysis of phosphorylation of YJL084c, a yeast protein. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34(4):433-8
{{SGDpaper|S000087197}} PMID 16278933</ref>
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{{SGDpaper|S000070355}} PMID 12098764</ref>
 
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Revision as of 13:05, 18 February 2011

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Systematic name YJL084C
Gene name ALY2
Aliases ART3
Feature type ORF, Verified
Coordinates Chr X:278002..274862
Primary SGDID S000003620


Description of YJL084C: Protein that promotes endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; acts as an adaptor to bring together Rsp5p with substrate Dip5p; phosphorylated by cyclin-CDK complex Pcl7p-Pho85p[1][2]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]





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References

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  1. Hatakeyama R, et al. (2010) Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2. Mol Cell Biol 30(24):5598-607 SGD PMID 20956561
  2. Shi XZ and Ao SZ (2002) Analysis of phosphorylation of YJL084c, a yeast protein. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34(4):433-8 SGD PMID 12098764
  3. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  4. submitted by Jeff Ubersax on 2004-01-27

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