Difference between revisions of "YPR140W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XVI:814387..815532
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|nowrap| Chr XVI:814391..815536
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006344
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006344

Revision as of 14:05, 3 February 2011

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Systematic name YPR140W
Gene name TAZ1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:814391..815536
Primary SGDID S000006344


Description of YPR140W: Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome[1][2][3]




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References

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  1. Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 SGD PMID 14651618
  2. Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 SGD PMID 9259571
  3. Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 SGD PMID 15588229

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