Difference between revisions of "YOL006C"
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XV: | + | |nowrap| Chr XV:315387..313078 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005366 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005366 | ||
Revision as of 14:05, 3 February 2011
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| Systematic name | YOL006C |
| Gene name | TOP1 |
| Aliases | MAK1, MAK17 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:315387..313078 |
| Primary SGDID | S000005366 |
Description of YOL006C: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination[1][2][3]
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Contents
Community Commentary
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References
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- ↑ Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
- ↑ Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 SGD PMID 2989818
- ↑ Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 SGD PMID 14585933
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