Difference between revisions of "YNL072W"
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| − | '''Description of YNL072W:''' Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI | + | '''Description of YNL072W:''' Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome<ref name='S000128478'>Crow YJ, et al. (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6 {{SGDpaper|S000128478}} PMID 16845400</ref><ref name='S000050269'>Frank P, et al. (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6 {{SGDpaper|S000050269}} PMID 9462832</ref><ref name='S000136054'>Nick McElhinny SA, et al. (2010) Genome instability due to ribonucleotide incorporation into DNA. Nat Chem Biol 6(10):774-81 {{SGDpaper|S000136054}} PMID 20729855</ref><ref name='S000048942'>Qiu J, et al. (1999) Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol 19(12):8361-71 |
{{SGDpaper|S000048942}} PMID 10567561</ref> | {{SGDpaper|S000048942}} PMID 10567561</ref> | ||
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Revision as of 13:05, 5 January 2011
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| Systematic name | YNL072W |
| Gene name | RNH201 |
| Aliases | RNH35 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:490319..491242 |
| Primary SGDID | S000005016 |
Description of YNL072W: Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome[1][2][3][4]
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References
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- ↑ Crow YJ, et al. (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6 SGD PMID 16845400
- ↑ Frank P, et al. (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6 SGD PMID 9462832
- ↑ Nick McElhinny SA, et al. (2010) Genome instability due to ribonucleotide incorporation into DNA. Nat Chem Biol 6(10):774-81 SGD PMID 20729855
- ↑ Qiu J, et al. (1999) Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol 19(12):8361-71 SGD PMID 10567561
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