Difference between revisions of "YKL084W"
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| − | '''Description of YKL084W:''' | + | '''Description of YKL084W:''' Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc<ref name='S000077347'>Curran SP, et al. (2004) The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem 279(42):43744-51 {{SGDpaper|S000077347}} PMID 15294910</ref><ref name='S000135685'>Mesecke N, et al. (2008) The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. EMBO Rep 9(11):1107-13 |
| − | {{SGDpaper| | + | {{SGDpaper|S000135685}} PMID 18787558</ref> |
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Revision as of 14:05, 29 November 2010
Share your knowledge...Edit this entry! <protect>
| Systematic name | YKL084W |
| Gene name | HOT13 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:280153..280503 |
| Primary SGDID | S000001567 |
Description of YKL084W: Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc[1][2]
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References
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- ↑ Curran SP, et al. (2004) The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem 279(42):43744-51 SGD PMID 15294910
- ↑ Mesecke N, et al. (2008) The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. EMBO Rep 9(11):1107-13 SGD PMID 18787558
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