Difference between revisions of "YPR041W"
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| − | '''Description of YPR041W:''' Translation initiation factor | + | '''Description of YPR041W:''' Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2<ref name='S000082127'>Asano K, et al. (2000) A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev 14(19):2534-46 {{SGDpaper|S000082127}} PMID 11018020</ref><ref name='S000065405'>Das S, et al. (2001) Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. J Biol Chem 276(9):6720-6 {{SGDpaper|S000065405}} PMID 11092890</ref><ref name='S000134638'>Jennings MD and Pavitt GD (2010) eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 465(7296):378-81 |
| − | {{SGDpaper| | + | {{SGDpaper|S000134638}} PMID 20485439</ref> |
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Revision as of 14:05, 25 October 2010
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| Systematic name | YPR041W |
| Gene name | TIF5 |
| Aliases | SUI5 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:648701..649918 |
| Primary SGDID | S000006245 |
Description of YPR041W: Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2[1][2][3]
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References
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- ↑ Asano K, et al. (2000) A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev 14(19):2534-46 SGD PMID 11018020
- ↑ Das S, et al. (2001) Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. J Biol Chem 276(9):6720-6 SGD PMID 11092890
- ↑ Jennings MD and Pavitt GD (2010) eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 465(7296):378-81 SGD PMID 20485439
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