Difference between revisions of "YDR346C"
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==Community Commentary== | ==Community Commentary== | ||
Revision as of 10:51, 24 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YDR346C | |
| Gene name | SVF1 | |
| Aliases | SGI1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:1168653..1167208 | |
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Description of YDR346C: Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis[1]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Complete Deletion
Strain Background: W303
Phenotype(s): Loss of function (Null), Temperature(Heat) Sensitive
Mutant shows decreased growth in glycerol and decreased ability to undergo diauxic shift. These phenotypes are corrected by expression of Bcl-xL. (Conversely, YDR346C has anti-apoptotic activity when expressed in mammalian cells.) Authors have named the gene SVF1, and found homology only to other fungal genes. They suggest that SVF1 may represent an as yet unknown family of genes responsible for adaptation to cellular stress. [1] [2]
References
See Help:References on how to add references
- ↑ 1.0 1.1 Vander Heiden MG, et al. (2002) Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. J Biol Chem 277(47):44870-6
SGD PMID 12244097 Cite error: Invalid
<ref>tag; name "S000071715" defined multiple times with different content - ↑ submitted by Matthew Brauer on 2003-08-28
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