Difference between revisions of "YGL207W"
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| − | '''Description of YGL207W:''' Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), | + | '''Description of YGL207W:''' Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases<ref name='S000074008'>Belotserkovskaya R, et al. (2003) FACT facilitates transcription-dependent nucleosome alteration. Science 301(5636):1090-3 {{SGDpaper|S000074008}} PMID 12934006</ref><ref name='S000072261'>Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 {{SGDpaper|S000072261}} PMID 12524332</ref><ref name='S000130799'>Ransom M, et al. (2009) FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation. J Biol Chem 284(35):23461-71 {{SGDpaper|S000130799}} PMID 19574230</ref><ref name='S000131309'>Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 |
| − | {{SGDpaper| | + | {{SGDpaper|S000131309}} PMID 19683499</ref> |
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Revision as of 13:05, 5 March 2010
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| Systematic name | YGL207W |
| Gene name | SPT16 |
| Aliases | CDC68, SSF1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:98973..102080 |
| Primary SGDID | S000003175 |
Description of YGL207W: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases[1][2][3][4]
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References
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- ↑ Belotserkovskaya R, et al. (2003) FACT facilitates transcription-dependent nucleosome alteration. Science 301(5636):1090-3 SGD PMID 12934006
- ↑ Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 SGD PMID 12524332
- ↑ Ransom M, et al. (2009) FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation. J Biol Chem 284(35):23461-71 SGD PMID 19574230
- ↑ Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 SGD PMID 19683499
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