Difference between revisions of "YGR184C"
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| − | '''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name=' | + | '''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 {{SGDpaper|S000126742}} PMID 18566452</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 |
| − | + | {{SGDpaper|S000132192}} PMID 16311597</ref> | |
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Revision as of 13:05, 25 February 2010
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| Systematic name | YGR184C |
| Gene name | UBR1 |
| Aliases | PTR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:865758..859906 |
| Primary SGDID | S000003416 |
Description of YGR184C: E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)[1][2][3][4][5][6]
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References
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- ↑ Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 SGD PMID 2209542
- ↑ Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 SGD PMID 9427760
- ↑ Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 SGD PMID 1651502
- ↑ Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 SGD PMID 18566452
- ↑ Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
- ↑ Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 SGD PMID 16311597
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