Difference between revisions of "YJL090C"

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'''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9
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'''Description of YJL090C:''' Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000120052'>Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 {{SGDpaper|S000120052}} PMID 17167415</ref><ref name='S000132428'>Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 {{SGDpaper|S000132428}} PMID 17167417</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000128433'>Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4
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Revision as of 14:05, 14 December 2009

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Systematic name YJL090C
Gene name DPB11
Aliases
Feature type ORF, Verified
Coordinates Chr X:265045..262751
Primary SGDID S000003626


Description of YJL090C: Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1[1][2][3][4][5][6][7]




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References

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  1. ↑ Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 SGD PMID 10733584
  2. ↑ Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
  3. ↑ Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 SGD PMID 9742127
  4. ↑ Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 SGD PMID 17167415
  5. ↑ Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 SGD PMID 17167417
  6. ↑ Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 SGD PMID 18922789
  7. ↑ Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4 SGD PMID 19028869

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