Difference between revisions of "YIL144W"
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| + | === Alleles, Strains, and Phenotypes === | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
| + | ==== Other Alleles, Strains... ==== | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes:Other Alleles, Strains...]] | ||
| + | '''Allele''': ndc80-dt<br> | ||
| + | '''Other Topic''': degron tagged mutant [[Category:Topic:degron tagged mutant]] | ||
| + | '''Strain Background''': W303a<br> | ||
| + | '''Genotype''': 3053 MATa ura3-1 leu2-2,112 his3-11,15 trp1-1 ade2-1 ndc80-dt :URA3 PGAL10-UBR1:HIS3<br> | ||
| + | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]] | ||
| + | |||
| + | Degron tagged ndc80 mutants are spindle checkpoint proficient. Mutants arrest in mitosis under restrictive conditions when protein is eliminated. Phenotype similar to ndc80-1 missense mutant. <ref name='S000072450'>McCleland ML, et al. (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 17(1):101-14 {{SGDpaper|S000072450}} PMID 12514103</ref> <ref name = 'CAset732-2003-02-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=732 Dan Burke] on 2003-02-27</ref> | ||
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| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Alleles, Strains, and Phenotypes === | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
| + | ==== Other Alleles, Strains... ==== | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes:Other Alleles, Strains...]] | ||
| + | '''Allele''': ndc80-dt<br> | ||
| + | '''Other Topic''': degron tagged mutant [[Category:Topic:degron tagged mutant]] | ||
| + | |||
| + | '''Strain Background''': W303a<br> | ||
| + | '''Genotype''': 3053 MATa ura3-1 leu2-2,112 his3-11,15 trp1-1 ade2-1 ndc80-dt :URA3 PGAL10-UBR1:HIS3<br> | ||
| + | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]] | ||
| + | |||
| + | Degron tagged ndc80 mutants are spindle checkpoint proficient. Mutants arrest in mitosis under restrictive conditions when protein is eliminated. Phenotype similar to ndc80-1 missense mutant. <ref name='S000072450'>McCleland ML, et al. (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 17(1):101-14 {{SGDpaper|S000072450}} PMID 12514103</ref> <ref name = 'CAset732-2003-02-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=732 Dan Burke] on 2003-02-27</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YIL144W | |
| Gene name | TID3 | |
| Aliases | HEC1, NDC80 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IX:78074..80149 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YIL144W: Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering[1][2][3][4][5][6]
Alleles, Strains, and Phenotypes
Other Alleles, Strains...
Allele: ndc80-dt
Other Topic: degron tagged mutant
Strain Background: W303a
Genotype: 3053 MATa ura3-1 leu2-2,112 his3-11,15 trp1-1 ade2-1 ndc80-dt :URA3 PGAL10-UBR1:HIS3
Phenotype(s): Loss of function (Null), Recessive, Temperature(Heat) Sensitive
Degron tagged ndc80 mutants are spindle checkpoint proficient. Mutants arrest in mitosis under restrictive conditions when protein is eliminated. Phenotype similar to ndc80-1 missense mutant. [3] [7]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Other Alleles, Strains...
Allele: ndc80-dt
Other Topic: degron tagged mutant
Strain Background: W303a
Genotype: 3053 MATa ura3-1 leu2-2,112 his3-11,15 trp1-1 ade2-1 ndc80-dt :URA3 PGAL10-UBR1:HIS3
Phenotype(s): Loss of function (Null), Recessive, Temperature(Heat) Sensitive
Degron tagged ndc80 mutants are spindle checkpoint proficient. Mutants arrest in mitosis under restrictive conditions when protein is eliminated. Phenotype similar to ndc80-1 missense mutant. [3] [7]
References
See Help:References on how to add references
- ↑ He X, et al. (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206 SGD PMID 11511347
- ↑ Westermann S, et al. (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22 SGD PMID 14581449
- ↑ 3.0 3.1 3.2 McCleland ML, et al. (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 17(1):101-14 SGD PMID 12514103
- ↑ Janke C, et al. (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J 20(4):777-91 SGD PMID 11179222
- ↑ Wigge PA and Kilmartin JV (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152(2):349-60 SGD PMID 11266451
- ↑ Zheng L, et al. (1999) Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. Mol Cell Biol 19(8):5417-28 SGD PMID 10409732
- ↑ 7.0 7.1 submitted by Dan Burke on 2003-02-27
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