Difference between revisions of "YBL064C"
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| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Regulatory ==== | ||
| + | [[Category:Topic:Interactions:Regulatory]] | ||
| + | YBL064C is regulated by TOR1. [[Category:Regulated by TOR1]]Regulatory interaction with TOR1 [[Category:Regulatory Interactions with TOR1]]<br> | ||
| + | PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. <ref name='S000079874'>Monteiro G and Netto LE (2004) Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett 241(2):221-8 {{SGDpaper|S000079874}} PMID 15598536</ref> <ref name = 'CAset9246-2005-01-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2005-01-03</ref> | ||
| + | {{ShortCenteredHR}} | ||
| + | YBL064C is regulated by Msn2. [[Category:Regulated by Msn2]]Regulatory interaction with Msn2 [[Category:Regulatory Interactions with Msn2]]<br> | ||
| + | YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. <ref name='S000069137'>Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 {{SGDpaper|S000069137}} PMID 11827753</ref> <ref name = 'CAset9246-2003-03-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2003-03-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | YBL064C is regulated by Hap1. [[Category:Regulated by Hap1]]Regulatory interaction with Hap1 [[Category:Regulatory Interactions with Hap1]]<br> | ||
| + | YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. <ref name='S000069137'>Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 {{SGDpaper|S000069137}} PMID 11827753</ref> <ref name = 'CAset9246-2003-03-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2003-03-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Regulatory ==== | ||
| + | [[Category:Topic:Interactions:Regulatory]] | ||
| + | YBL064C is regulated by TOR1. [[Category:Regulated by TOR1]]Regulatory interaction with TOR1 [[Category:Regulatory Interactions with TOR1]]<br> | ||
| + | PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. <ref name='S000079874'>Monteiro G and Netto LE (2004) Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett 241(2):221-8 {{SGDpaper|S000079874}} PMID 15598536</ref> <ref name = 'CAset9246-2005-01-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2005-01-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | YBL064C is regulated by Msn2. [[Category:Regulated by Msn2]]Regulatory interaction with Msn2 [[Category:Regulatory Interactions with Msn2]]<br> | ||
| + | YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. <ref name='S000069137'>Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 {{SGDpaper|S000069137}} PMID 11827753</ref> <ref name = 'CAset9246-2003-03-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2003-03-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | YBL064C is regulated by Hap1. [[Category:Regulated by Hap1]]Regulatory interaction with Hap1 [[Category:Regulatory Interactions with Hap1]]<br> | ||
| + | YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. <ref name='S000069137'>Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 {{SGDpaper|S000069137}} PMID 11827753</ref> <ref name = 'CAset9246-2003-03-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2003-03-31</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YBL064C | |
| Gene name | PRX1 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr II:101158..100373 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YBL064C: Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress[1][2]
Interactions
Regulatory
YBL064C is regulated by TOR1.Regulatory interaction with TOR1
PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. [3] [4]
YBL064C is regulated by Msn2.Regulatory interaction with Msn2
YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. [5] [6]
YBL064C is regulated by Hap1.Regulatory interaction with Hap1
YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. [5] [6]
Contents
Community Commentary
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Interactions
Regulatory
YBL064C is regulated by TOR1.Regulatory interaction with TOR1
PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. [3] [4]
YBL064C is regulated by Msn2.Regulatory interaction with Msn2
YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. [5] [6]
YBL064C is regulated by Hap1.Regulatory interaction with Hap1
YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. [5] [6]
References
See Help:References on how to add references
- ↑ Pedrajas JR, et al. (2000) Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem 275(21):16296-301 SGD PMID 10821871
- ↑ Grant CM (2001) Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 39(3):533-41 SGD PMID 11169096
- ↑ 3.0 3.1 Monteiro G and Netto LE (2004) Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett 241(2):221-8 SGD PMID 15598536
- ↑ 4.0 4.1 submitted by Gisele Monteiro on 2005-01-03
- ↑ 5.0 5.1 5.2 5.3 Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 SGD PMID 11827753
- ↑ 6.0 6.1 6.2 6.3 submitted by Gisele Monteiro on 2003-03-31
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