Difference between revisions of "YOR278W"
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| − | '''Description of YOR278W:''' Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the | + | '''Description of YOR278W:''' Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria<ref name='S000040301'>Amillet JM and Labbe-Bois R (1995) Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae. Yeast 11(5):419-24 {{SGDpaper|S000040301}} PMID 7597845</ref><ref name='S000124836'>Tan FC, et al. (2008) Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Biochem J 410(2):291-9 |
| − | {{SGDpaper| | + | {{SGDpaper|S000124836}} PMID 18042043</ref> |
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Revision as of 13:05, 22 April 2009
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| Systematic name | YOR278W |
| Gene name | HEM4 |
| Aliases | SLU2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:842816..843643 |
| Primary SGDID | S000005804 |
Description of YOR278W: Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria[1][2]
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References
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- ↑ Amillet JM and Labbe-Bois R (1995) Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae. Yeast 11(5):419-24 SGD PMID 7597845
- ↑ Tan FC, et al. (2008) Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Biochem J 410(2):291-9 SGD PMID 18042043
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