Difference between revisions of "YPR062W"
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| − | '''Description of YPR062W:''' Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)<ref name=' | + | '''Description of YPR062W:''' Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)<ref name='S000054250'>Erbs P, et al. (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr Genet 31(1):1-6 {{SGDpaper|S000054250}} PMID 9000374</ref><ref name='S000081442'>Yao L, et al. (2005) Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. Biochemistry 44(15):5940-7 |
| − | {{SGDpaper| | + | {{SGDpaper|S000081442}} PMID 15823054</ref> |
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Revision as of 14:05, 31 March 2009
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| Systematic name | YPR062W |
| Gene name | FCY1 |
| Aliases | yCD |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:677162..677638 |
| Primary SGDID | S000006266 |
Description of YPR062W: Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)[1][2]
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References
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- ↑ Erbs P, et al. (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr Genet 31(1):1-6 SGD PMID 9000374
- ↑ Yao L, et al. (2005) Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. Biochemistry 44(15):5940-7 SGD PMID 15823054
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