Difference between revisions of "YLR035C"

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'''Description of YLR035C:''' Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p<ref name='S000077475'>Abdullah MF, et al. (2004) A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenet Genome Res 107(3-4):180-90 {{SGDpaper|S000077475}} PMID 15467363</ref><ref name='S000055563'>Wang TF, et al. (1999) Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc Natl Acad Sci U S A 96(24):13914-9 {{SGDpaper|S000055563}} PMID 10570173</ref><ref name='S000042567'>Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8
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'''Description of YLR035C:''' Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p<ref name='S000042567'>Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8 {{SGDpaper|S000042567}} PMID 10679328</ref><ref name='S000055563'>Wang TF, et al. (1999) Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc Natl Acad Sci U S A 96(24):13914-9 {{SGDpaper|S000055563}} PMID 10570173</ref><ref name='S000077475'>Abdullah MF, et al. (2004) A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenet Genome Res 107(3-4):180-90
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  {{SGDpaper|S000077475}} PMID 15467363</ref>
 
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Revision as of 13:05, 31 March 2009

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Systematic name YLR035C
Gene name MLH2
Aliases
Feature type ORF, Verified
Coordinates Chr XII:214457..212370
Primary SGDID S000004025


Description of YLR035C: Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8 SGD PMID 10679328
  2. Wang TF, et al. (1999) Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc Natl Acad Sci U S A 96(24):13914-9 SGD PMID 10570173
  3. Abdullah MF, et al. (2004) A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenet Genome Res 107(3-4):180-90 SGD PMID 15467363
  4. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  5. submitted by Jeff Ubersax on 2004-01-29

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