Difference between revisions of "YDL013W"
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| − | '''Description of YDL013W:''' Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers<ref name=' | + | '''Description of YDL013W:''' Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers<ref name='S000059086'>Mullen JR, et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18 {{SGDpaper|S000059086}} PMID 11139495</ref><ref name='S000113976'>Wang Z, et al. (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509 {{SGDpaper|S000113976}} PMID 16387868</ref><ref name='S000124057'>Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84 {{SGDpaper|S000124057}} PMID 17848550</ref><ref name='S000124762'>Ii T, et al. (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9 {{SGDpaper|S000124762}} PMID 18032921</ref><ref name='S000129620'>Cook CE, et al. (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9 |
| − | {{SGDpaper| | + | {{SGDpaper|S000129620}} PMID 19270524</ref> |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YDL013W |
| Gene name | SLX5 |
| Aliases | HEX3, ULS2 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:429065..430924 |
| Primary SGDID | S000002171 |
Description of YDL013W: Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers[1][2][3][4][5]
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References
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- ↑ Mullen JR, et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18 SGD PMID 11139495
- ↑ Wang Z, et al. (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509 SGD PMID 16387868
- ↑ Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84 SGD PMID 17848550
- ↑ Ii T, et al. (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9 SGD PMID 18032921
- ↑ Cook CE, et al. (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9 SGD PMID 19270524
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