Difference between revisions of "YOR038C"
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| − | '''Description of YOR038C:''' | + | '''Description of YOR038C:''' Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p<ref name='S000087068'>Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 {{SGDpaper|S000087068}} PMID 16264190</ref><ref name='S000065877'>Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 {{SGDpaper|S000065877}} PMID 11412995</ref><ref name='S000055143'>Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 {{SGDpaper|S000055143}} PMID 9001207</ref><ref name='S000048249'>Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 {{SGDpaper|S000048249}} PMID 8417331</ref><ref name='S000047900'>Dimova D, et al. (1999) A role for transcriptional repressors in targeting the yeast Swi/Snf complex. Mol Cell 4(1):75-83 {{SGDpaper|S000047900}} PMID 10445029</ref><ref name='S000043368'>Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 {{SGDpaper|S000043368}} PMID 9671489</ref><ref name='S000039248'>DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67 |
{{SGDpaper|S000039248}} PMID 9504914</ref> | {{SGDpaper|S000039248}} PMID 9504914</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YOR038C |
| Gene name | HIR2 |
| Aliases | SPT1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:405388..402761 |
| Primary SGDID | S000005564 |
Description of YOR038C: Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p[1][2][3][4][5][6][7]
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References
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- ↑ Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 SGD PMID 16264190
- ↑ Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 SGD PMID 11412995
- ↑ Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 SGD PMID 9001207
- ↑ Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 SGD PMID 8417331
- ↑ Dimova D, et al. (1999) A role for transcriptional repressors in targeting the yeast Swi/Snf complex. Mol Cell 4(1):75-83 SGD PMID 10445029
- ↑ Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 SGD PMID 9671489
- ↑ DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67 SGD PMID 9504914
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