Difference between revisions of "YOL115W"
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| − | '''Description of YOL115W:''' Catalytic subunit of TRAMP | + | '''Description of YOL115W:''' Catalytic subunit of TRAMP, a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; has 5'-dRP lyase activity; disputed role as a DNA polymerase<ref name='S000124622'>Gellon L, et al. (2008) Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. DNA Repair (Amst) 7(2):187-98 {{SGDpaper|S000124622}} PMID 17983848</ref><ref name='S000081864'>Wyers F, et al. (2005) Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell 121(5):725-37 {{SGDpaper|S000081864}} PMID 15935759</ref><ref name='S000081843'>LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 {{SGDpaper|S000081843}} PMID 15935758</ref><ref name='S000081438'>Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 {{SGDpaper|S000081438}} PMID 15828860</ref><ref name='S000081293'>Saitoh S, et al. (2002) Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109(5):563-73 {{SGDpaper|S000081293}} PMID 12062100</ref><ref name='S000069232'>Wang Z, et al. (2002) Structure/function analysis of the Saccharomyces cerevisiae Trf4/Pol sigma DNA polymerase. Genetics 160(2):381-91 {{SGDpaper|S000069232}} PMID 11861546</ref><ref name='S000055910'>Wang Z, et al. (2000) Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science 289(5480):774-9 |
{{SGDpaper|S000055910}} PMID 10926539</ref> | {{SGDpaper|S000055910}} PMID 10926539</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YOL115W |
| Gene name | PAP2 |
| Aliases | TRF4 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:101475..103229 |
| Primary SGDID | S000005475 |
Description of YOL115W: Catalytic subunit of TRAMP, a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; has 5'-dRP lyase activity; disputed role as a DNA polymerase[1][2][3][4][5][6][7]
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References
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- ↑ Gellon L, et al. (2008) Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. DNA Repair (Amst) 7(2):187-98 SGD PMID 17983848
- ↑ Wyers F, et al. (2005) Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell 121(5):725-37 SGD PMID 15935759
- ↑ LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
- ↑ Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860
- ↑ Saitoh S, et al. (2002) Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109(5):563-73 SGD PMID 12062100
- ↑ Wang Z, et al. (2002) Structure/function analysis of the Saccharomyces cerevisiae Trf4/Pol sigma DNA polymerase. Genetics 160(2):381-91 SGD PMID 11861546
- ↑ Wang Z, et al. (2000) Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science 289(5480):774-9 SGD PMID 10926539
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