Difference between revisions of "YMR224C"
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| − | '''Description of YMR224C:''' Subunit of a complex with Rad50p and Xrs2p ( | + | '''Description of YMR224C:''' Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved<ref name='S000076170'>Lewis LK, et al. (2004) Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166(4):1701-13 {{SGDpaper|S000076170}} PMID 15126391</ref><ref name='S000075411'>Moncalian G, et al. (2004) The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol 335(4):937-51 {{SGDpaper|S000075411}} PMID 14698290</ref><ref name='S000069971'>D'Amours D and Jackson SP (2002) The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 3(5):317-27 |
{{SGDpaper|S000069971}} PMID 11988766</ref> | {{SGDpaper|S000069971}} PMID 11988766</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YMR224C |
| Gene name | MRE11 |
| Aliases | NGS1, RAD58, XRS4 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:720652..718574 |
| Primary SGDID | S000004837 |
Description of YMR224C: Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved[1][2][3]
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References
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- ↑ Lewis LK, et al. (2004) Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166(4):1701-13 SGD PMID 15126391
- ↑ Moncalian G, et al. (2004) The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol 335(4):937-51 SGD PMID 14698290
- ↑ D'Amours D and Jackson SP (2002) The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 3(5):317-27 SGD PMID 11988766
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