Difference between revisions of "YMR159C"
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| − | '''Description of YMR159C:''' | + | '''Description of YMR159C:''' Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy<ref name='S000120213'>Meijer WH, et al. (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3(2):106-16 {{SGDpaper|S000120213}} PMID 17204848</ref><ref name='S000069879'>Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 {{SGDpaper|S000069879}} PMID 11897782</ref><ref name='S000068967'>Suzuki K, et al. (2001) The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20(21):5971-81 {{SGDpaper|S000068967}} PMID 11689437</ref><ref name='S000040381'>Mizushima N, et al. (1999) Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J 18(14):3888-96 |
{{SGDpaper|S000040381}} PMID 10406794</ref> | {{SGDpaper|S000040381}} PMID 10406794</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YMR159C |
| Gene name | ATG16 |
| Aliases | APG15, APG16, CVT11, SAP18 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:574927..574475 |
| Primary SGDID | S000004769 |
Description of YMR159C: Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy[1][2][3][4]
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References
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- ↑ Meijer WH, et al. (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3(2):106-16 SGD PMID 17204848
- ↑ Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 SGD PMID 11897782
- ↑ Suzuki K, et al. (2001) The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20(21):5971-81 SGD PMID 11689437
- ↑ Mizushima N, et al. (1999) Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J 18(14):3888-96 SGD PMID 10406794
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