Difference between revisions of "YLR288C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MEC3 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MEC3 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''PIP3''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''PIP3, PSO9''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]

Revision as of 07:21, 26 February 2009

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Systematic name YLR288C
Gene name MEC3
Aliases PIP3, PSO9
Feature type ORF, Verified
Coordinates Chr XII:714906..713482
Primary SGDID S000004279


Description of YLR288C: DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1[1][2][3][4][5]




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References

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  1. Rouse J and Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297(5581):547-51 SGD PMID 12142523
  2. Majka J and Burgers PM (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54 SGD PMID 12604797
  3. Hong EJ and Roeder GS (2002) A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. Genes Dev 16(3):363-76 SGD PMID 11825877
  4. de la Torre-Ruiz M and Lowndes NF (2000) The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining. FEBS Lett 467(2-3):311-5 SGD PMID 10675560
  5. Kondo T, et al. (1999) Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol Cell Biol 19(2):1136-43 SGD PMID 9891048

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