Difference between revisions of "YJL090C"
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr X: | + | |nowrap| Chr X:265045..262751 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003626 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003626 | ||
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| − | '''Description of YJL090C:''' | + | '''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 |
{{SGDpaper|S000043352}} PMID 10733584</ref> | {{SGDpaper|S000043352}} PMID 10733584</ref> | ||
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Revision as of 06:21, 26 February 2009
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| Systematic name | YJL090C |
| Gene name | DPB11 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:265045..262751 |
| Primary SGDID | S000003626 |
Description of YJL090C: Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity[1][2][3][4][5][6][7]
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References
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- ↑ Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 SGD PMID 18922789
- ↑ Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 SGD PMID 12865298
- ↑ Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 SGD PMID 11973288
- ↑ Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 SGD PMID 9742127
- ↑ Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 SGD PMID 10545450
- ↑ Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
- ↑ Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 SGD PMID 10733584
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