Difference between revisions of "YBR270C"

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'''Description of YBR270C:''' Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p<ref name='S000042595'>Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5 {{SGDpaper|S000042595}} PMID 8943012</ref><ref name='S000080639'>Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 {{SGDpaper|S000080639}} PMID 15689497</ref><ref name='S000119407'>De Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415 {{SGDpaper|S000119407}} PMID 17041625</ref><ref name='S000126051'>Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60
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'''Description of YBR270C:''' Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p<ref name='S000126051'>Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60 {{SGDpaper|S000126051}} PMID 18396450</ref><ref name='S000119407'>De Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415 {{SGDpaper|S000119407}} PMID 17041625</ref><ref name='S000080639'>Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 {{SGDpaper|S000080639}} PMID 15689497</ref><ref name='S000042595'>Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5
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  {{SGDpaper|S000042595}} PMID 8943012</ref>
 
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Revision as of 13:05, 16 January 2009

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Systematic name YBR270C
Gene name BIT2
Aliases
Feature type ORF, Uncharacterized
Coordinates Chr II:744393..742756
Primary SGDID S000000474


Description of YBR270C: Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p[1][2][3][4]




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References

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  1. Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60 SGD PMID 18396450
  2. De Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415 SGD PMID 17041625
  3. Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 SGD PMID 15689497
  4. Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5 SGD PMID 8943012

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