Difference between revisions of "YHR068W"
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| − | '''Description of YHR068W:''' Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric<ref name=' | + | '''Description of YHR068W:''' Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric<ref name='S000039694'>Kang KR, et al. (1995) Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme. J Biol Chem 270(31):18408-12 {{SGDpaper|S000039694}} PMID 7629166</ref><ref name='S000046348'>Abid R, et al. (1997) Novel features of the functional site and expression of the yeast deoxyhypusine synthase. Biol Signals 6(3):157-65 {{SGDpaper|S000046348}} PMID 9285099</ref><ref name='S000075161'>Thompson GM, et al. (2003) Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. FEBS Lett 555(3):464-8 |
| − | {{SGDpaper| | + | {{SGDpaper|S000075161}} PMID 14675757</ref> |
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Revision as of 03:40, 18 December 2008
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| Systematic name | YHR068W |
| Gene name | DYS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:232135..233298 |
| Primary SGDID | S000001110 |
Description of YHR068W: Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric[1][2][3]
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References
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- ↑ Kang KR, et al. (1995) Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme. J Biol Chem 270(31):18408-12 SGD PMID 7629166
- ↑ Abid R, et al. (1997) Novel features of the functional site and expression of the yeast deoxyhypusine synthase. Biol Signals 6(3):157-65 SGD PMID 9285099
- ↑ Thompson GM, et al. (2003) Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. FEBS Lett 555(3):464-8 SGD PMID 14675757
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