Difference between revisions of "YDL003W"

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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner.
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MBC 19(5):2127-34,2008
  
 
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==References==
 
==References==
 
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Revision as of 10:20, 29 April 2008

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Systematic name YDL003W
Gene name MCD1
Aliases PDS3, RHC21, SCC1
Feature type ORF, Verified
Coordinates Chr IV:444680..446380
Primary SGDID S000002161


Description of YDL003W: Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase[1]




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Community Commentary

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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner. MBC 19(5):2127-34,2008




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References

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  1. Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57 SGD PMID 9335334

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