YOR269W - Revision history

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{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOR269W YOR269W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PAC1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:826384..827868
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1<ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64 {{SGDpaper|S000072477}} PMID 12566428</ref><ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27
{{SGDpaper|S000048840}} PMID 10567527</ref>
 
 
 
 

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==Community Commentary==
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==References==

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-'''Description of YOR269W:''' Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1<ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27 {{SGDpaper|S000048840}} PMID 10567527</ref><ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64
+'''Description of YOR269W:''' Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly<ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27 {{SGDpaper|S000048840}} PMID 10567527</ref><ref name='S000150968'>Huang J, et al. (2012) Lis1 Acts as a Clutch between the ATPase and Microtubule-Binding Domains of the Dynein Motor. Cell 150(5):975-86 {{SGDpaper|S000150968}} PMID 22939623</ref><ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64
   {{SGDpaper|S000072477}} PMID 12566428</ref>
 <br>

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 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:826384..827868
+|nowrap| Chr XV:826385..827869
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005795

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR269W:''' Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1<ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64 {{SGDpaper|S000072477}} PMID 12566428</ref><ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27
+'''Description of YOR269W:''' Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1<ref name='S000048840'>Fujiwara T, et al. (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27 {{SGDpaper|S000048840}} PMID 10567527</ref><ref name='S000072477'>Lee WL, et al. (2003) The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. J Cell Biol 160(3):355-64
-  {{SGDpaper|S000048840}} PMID 10567527</ref>
+  {{SGDpaper|S000072477}} PMID 12566428</ref>
 <br>
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← Older revision		Revision as of 20:02, 21 February 2007
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		+
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005795 YOR269W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005795 YOR269W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''PAC1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:826384..827868
 |}
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 __TOC__
 ==Community Commentary==
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 ==References==
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 {{RefHelp}}